OBJECTIVE:
to determine tablet friability
INTRODUCTION:
Friability
is the tendency for a tablet to chip, crumble or break following compression.
This tendency is normally confined to uncoated tablets and surfaces during handling
or subsequent storage. It can be caused by a number of factors including poor
tablet design (too sharp edges), low moisture content, insufficient binder,
etc. Tablets must be
able to withstand mechanical stresses during their manufacturing, distribution
and handling by the end-user. Friability is a measure of the resistance of the
tablets to shipping and abrasion by tumbling them in a rotating drum. After
tumbling, the integrity of the tablets and the weight loss are evaluated.
Tablet hardness testing is also called tablet breaking force testing. For this
test the tablets are placed between two plates. One of the plates moves in
order to damage the tablet. The breaking force is the force required to break
or damage the tablets in a specific plane. Tablet breaking force measurement is
frequently used as an alternative to compression force measurement. This is an
essential quality control parameter since compression influences many tablet
properties including disintegration, dissolution and friability.
For
obvious reasons, tablets need to be hard enough such that they do not break up
in the bottle but friable enough that they disintegrate in the gastrointestinal
tract.
METHODOLOGY :
Apparatus and materials:
Methyldopa tablets 250mg
Friability tester
Electronic balance
Procedure:
Apparatus and materials:
Methyldopa tablets 250mg
Friability tester
Electronic balance
Procedure:
1.
10
tablets was selected and being weighed.
2.
All
tablets was put into the drum of the tablets abration and friability tester. The rate of rotation
was set at 25 rpm, in 10 minutes and the operation was started.
3.
At
the end of the operation, all the tablets were removed and ensured the freedom
from dust or powder (use the brush). The tablets was reweighed and the
percentage of weight loss was determined.
4.
Compressed
tablet should nor lose more than 1% of its weight.
RESULTS:
Drug’s
name: Methyldopa tablet 250 mg
Initial weight (g)
|
3.5262 g
|
Final weight (g)
|
3.5086 g
|
Total weight loss
(g)
|
0.0176 g
|
DISCUSSION
:
From the
result, there are slightly loss of weight after tablets inserted into the drum
of the tablets abration and friability
tester. Sample complies if loss of weight is less than 1.0 % and sample fails
if there are tablets cracks, cleaved or broken. This shows that the tablets may
be perfectly coated and hard enough and can withstand mechanical stressed that
put on it.
CONCLUSION:
From the
experiment, we can conclude that the tablet is a success and test of friability
as the weight loss is less than 1.0 %. Low friability can be caused by a number
of factors including poor tablet design (too sharp edges), low moisture
content, insufficient binder, etc. Tablets must be able to withstand mechanical
stresses during their manufacturing, and distribution so that they are hard
enough and not easily breaks.
REFERENCES:
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